GHK-Cu Copper Peptide Overview

GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycyl-L-histidyl-L-lysine. It is endogenously present in human plasma, saliva, and urine and has been the subject of extensive scientific investigation due to its regenerative and protective biological effects. Research has consistently shown that GHK-Cu plays a significant role in tissue repair by activating fibroblasts, modulating immune responses, and supporting cellular processes involved in wound healing and skin renewal.

Skin Regeneration and Anti-Aging Effects of GHK-Cu

Stimulation of Collagen and Extracellular Matrix Proteins

GHK-Cu supports skin repair by reducing oxidative stress and inflammation while stimulating the synthesis of collagen and other extracellular matrix components essential for skin structure. These actions contribute to improved skin firmness, elasticity, and overall texture, while also reducing scar formation and visible signs of aging. Because of these properties, GHK-Cu has been widely incorporated into advanced dermatological and cosmetic research formulations.

Supported by:
Pickart et al., BioMed Research International (Hindawi); Pickart & Margolina, International Journal of Molecular Sciences (MDPI)

Protection Against Photoaging and Wrinkle Formation

Experimental and clinical studies indicate that GHK-Cu can counteract damage caused by ultraviolet radiation. By promoting tissue remodeling and normalizing gene expression related to skin repair, GHK-Cu helps improve the appearance of photoaged skin, reducing fine lines and restoring a healthier, more youthful skin profile.

Supported by:
Dou et al., Clinical, Cosmetic and Investigational Dermatology (PubMed-indexed)

Promotion of Angiogenesis

Adequate blood supply is critical for tissue regeneration. GHK-Cu has been shown to stimulate angiogenesis, supporting the formation of new blood vessels that enhance oxygen and nutrient delivery to damaged tissue and accelerate healing.

Supported by:
Zhao et al., Wound Repair and Regeneration (Wiley Online Library)

Wound Healing and Protective Properties

Enhancement of Wound Repair

GHK-Cu has demonstrated the ability to accelerate wound closure and improve healing outcomes in experimental models, including compromised healing environments. Studies involving diabetic and ischemic wound models show improved tissue regeneration, reduced inflammation, and enhanced vascularization when GHK-Cu is applied.

Supported by:
Zhao et al., Wound Repair and Regeneration (Wiley); Pickart et al., BioMed Research International (Hindawi)

Antioxidant and Cytoprotective Activity

GHK-Cu exhibits strong antioxidant properties by modulating genes associated with oxidative stress and inflammation. This activity protects tissues from further damage during healing and contributes to long-term tissue integrity.

Supported by:
Pickart et al., Oxidative Medicine and Cellular Longevity (Hindawi)

Neuroprotective and Anti-Degenerative Potential

GHK-Cu is present in relatively high concentrations within the nervous system, where it supports neuronal health. Levels of this peptide decline with age, a change that may contribute to neurodegenerative processes. Laboratory studies suggest that GHK-Cu promotes nerve growth, suppresses inflammatory signaling, enhances vascular development in neural tissue, and favorably regulates gene expression patterns associated with aging and degeneration. These findings suggest potential relevance to age-related neurological decline, including pathways implicated in Alzheimer’s disease.

Supported by:
Pickart & Margolina, International Journal of Molecular Sciences (MDPI); Pickart et al., BioMed Research International(Hindawi)

GHK-Cu Copper Peptide Specifications

• CAS Number: 89030-95-5

• Molecular Formula: C₁₄H₂₂CuN₆O₄

• Sequence: (Gly-His-Lys)-Cu

• Molecular Weight: 340.38 g/mol

• Peptide Class: Tripeptide

• Form: Lyophilized powder in sterile glass vial

• Purity: ≥98%

• Quantity: 50 mg per vial

• Color: Purple (characteristic of copper coordination)

• Storage: Refrigerate after reconstitution

Important Notice

This compound is supplied exclusively for in vitro laboratory research by qualified professionals. It is not approved by the U.S. FDA for human or veterinary use and must not be marketed, labeled, or represented as a drug, dietary supplement, cosmetic, or food product.

References

1. Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide. International Journal of Molecular Sciences. MDPI.
   https://www.mdpi.com/1422-0067/19/7/1987

2. Pickart L. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International. Hindawi.
   https://www.hindawi.com/journals/bmri/2015/648108/

3. Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in prevention of oxidative stress.Oxidative Medicine and Cellular Longevity. Hindawi.
   https://www.hindawi.com/journals/omcl/2012/324832/

4. Dou X et al. The potential of GHK as an anti-aging peptide. Clinical, Cosmetic and Investigational Dermatology. PubMed-indexed.
   https://pubmed.ncbi.nlm.nih.gov/35083444/

5. Zhao R et al. GHK-Cu-liposomes accelerate scald wound healing in mice. Wound Repair and Regeneration.Wiley Online Library.
   https://onlinelibrary.wiley.com/doi/10.1111/wrr.12550

6. Pickart L. The human tripeptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition.Taylor & Francis.

7. Hostynek JJ, Maibach HI. Copper tripeptides. Dermatotoxicology and Pharmacology. Springer.

8. Lau S-J et al. The interaction of copper (II) and glycyl-L-histidyl-L-lysine. Biochemical Journal. Portland Press.

9. Frontiers Editorial. Innovation and transformation of chronic airway diseases. Frontiers in Medicine.
   (Used for systemic oxidative-stress and regenerative signaling context)

Complete Disclaimer

This product is sold exclusively for laboratory research purposes under Section 351 of the Public Health Service Act. It is not intended for human or veterinary use, nor for diagnostic, therapeutic, or cosmetic applications. Purchaser certifies they are properly licensed and equipped to handle research compounds in compliance with all local, state, and federal regulations. EaglePeptidesUSA assumes no liability for misuse or unauthorized handling. By purchasing, you affirm this material will not be introduced into interstate commerce or used in food/drug products.